The description of the protein encoded in this ORF: v-myb myeloblastosis viral oncogene homolog
The translational frameshift (ribosome slippage) involved: 0
The ribosome read-through involved: no
The alternative forms of this protein occur by the alternative initiation of translation: not tested
The ORF absolute position (the base range includes START and STOP codons or their equivalents): 200-2122
Several splice variants exist in human. A great survey of them is annotated in GI:1872199. The same 5'-UTR as
within this IRESite record is present in splice variant 8 (GI:45502008), 8A (GI:45502002), 8B (GI:45502010),
9Ai (GI:45502004), 9Aii (GI:45502006), 10A (GI:45502012), 13A (GI:45502014), 14A (GI:45502016).
Possibility of cryptic promoter presence was excluded by the use of a promoter-less plasmid (Mitchell et al.
(2005), Figure 3D). Possibility of aberrantly spliced products was only studied by Northern blot (Mitchell et
al. (2005), Figure 3C).
The IRES name: MYB Warning: please make ires_name same as the gene_name and optionally append to it coordinates. E.g. when gene/virus name is EMCV-R use EMCV-R_-222_to_-1 or EMCV-R_1-456, etc. but not Emcv-R-... or EMCV-222_to_-1. Please keep case of letters as well. This rewards when searching through the database.
The IRES absolute position (the range includes START and STOP codons or their equivalents): 2-151
How IRES boundaries were determined: experimentally_determined
The sequence of IRES region aligned to its secondary structure (if available):
Results of mutational IRES analysis were shown in Figure 6A, left column.
ITAF fullname: polypyrimidine tract-binding protein isoform 1
ITAF description (long): polypyrimidine tract-binding protein isoform 1 binds dsRNA with (CCU)n motif where n is at least 3. By SELEX
approach it was found it binds to 5'-CAGCCUGGUGCCUCUCUUUCGG-3' (Singh et al. (1995) Science 268:1173-1176)
but also UCUU or UCUUC within pyrimidine-rich sequence (Perez et al. (1997) RNA3:1334-1347).
3.1.2. Organisms or in vitro systems where this ITAF was functionally studied:
Organism or in vitro system where ITAF was shown:
Necessity of ITAF for translation in this particular organism or system: required_but_available_internally
Method used to demonstrate ITAF effect: in_vivo
The organism where action of this ITAF was studied: